home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-06 | 279.7 KB |
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MacOS 8.1
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Win98
|
DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
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|000004b0| 00 00 00 01 5f ae 03 00 | 5f 0a 00 00 38 35 00 00 |...._...|_...85..|
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|000004d0| 16 c1 03 00 61 0c 00 00 | 38 37 00 00 00 01 77 cd |....a...|87....w.|
|000004e0| 03 00 0d 0a 00 00 38 38 | 00 00 00 01 84 d7 03 00 |......88|........|
|000004f0| 13 0e 00 00 38 39 00 00 | 00 01 97 e5 03 00 81 08 |....89..|........|
|00000500| 00 00 39 30 00 00 00 01 | 18 ee 03 00 eb 0a 00 00 |..90....|........|
|00000510| 39 31 00 00 00 01 03 f9 | 03 00 53 0c 00 00 39 32 |91......|..S...92|
|00000520| 00 00 00 01 56 05 04 00 | 30 0e 00 00 39 33 00 00 |....V...|0...93..|
|00000530| 00 01 86 13 04 00 f0 0b | 00 00 39 34 00 00 00 01 |........|..94....|
|00000540| 76 1f 04 00 c0 0a 00 00 | 39 35 00 00 00 01 36 2a |v.......|95....6*|
|00000550| 04 00 ab 0a 00 00 39 36 | 00 00 00 01 e1 34 04 00 |......96|.....4..|
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|00000580| 39 39 00 00 00 01 fd 53 | 04 00 d2 0a 00 00 00 00 |99.....S|........|
|00000590| 00 00 00 00 cf 5e 04 00 | 00 00 00 00 24 55 6e 69 |.....^..|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 31 30 30 30 30 7d |que_ID{Y|RB10000}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 45 66 66 65 63 74 73 |..$Title|{Effects|
|000005c0| 20 6f 66 20 50 72 6f 6c | 6f 6e 67 65 64 20 4e 61 | of Prol|onged Na|
|000005d0| 6c 6f 78 6f 6e 65 20 49 | 6e 66 75 73 69 6f 6e 20 |loxone I|nfusion |
|000005e0| 69 6e 20 53 65 70 74 69 | 63 20 53 68 6f 63 6b 7d |in Septi|c Shock}|
|000005f0| 0d 0a 24 41 75 74 68 6f | 72 7b 52 6f 62 65 72 74 |..$Autho|r{Robert|
|00000600| 73 2c 20 44 45 0d 0a 44 | 6f 62 73 6f 6e 2c 20 4b |s, DE..D|obson, K|
|00000610| 45 0d 0a 48 61 6c 6c 2c | 20 4b 57 0d 0a 4c 69 67 |E..Hall,| KW..Lig|
|00000620| 68 74 2c 20 52 42 7d 0d | 0a 24 41 66 66 69 6c 69 |ht, RB}.|.$Affili|
|00000630| 61 74 69 6f 6e 7b 48 65 | 61 6c 74 68 20 53 63 69 |ation{He|alth Sci|
|00000640| 65 6e 63 65 73 20 43 74 | 72 2c 20 57 69 6e 6e 69 |ences Ct|r, Winni|
|00000650| 70 65 67 2c 20 4d 61 6e | 7d 0d 0a 24 4a 6f 75 72 |peg, Man|}..$Jour|
|00000660| 6e 61 6c 7b 4c 61 6e 63 | 65 74 7d 0d 0a 24 56 6f |nal{Lanc|et}..$Vo|
|00000670| 6c 75 6d 65 7b 32 7d 0d | 0a 24 50 61 67 65 7b 36 |lume{2}.|.$Page{6|
|00000680| 39 39 2d 37 30 32 7d 0d | 0a 24 44 61 74 65 7b 53 |99-702}.|.$Date{S|
|00000690| 65 70 74 20 32 34 2c 20 | 31 39 38 38 7d 0d 0a 24 |ept 24, |1988}..$|
|000006a0| 59 42 56 6f 6c 7b 31 39 | 39 30 20 59 65 61 72 20 |YBVol{19|90 Year |
|000006b0| 42 6f 6f 6b 20 6f 66 20 | 44 72 75 67 20 54 68 65 |Book of |Drug The|
|000006c0| 72 61 70 79 7d 0d 0a 24 | 43 68 61 70 74 65 72 7b |rapy}..$|Chapter{|
|000006d0| 31 30 2d 31 33 7d 0d 0a | 24 59 42 45 64 69 74 6f |10-13}..|$YBEdito|
|000006e0| 72 7b 44 72 73 2e 20 48 | 6f 6c 6c 69 73 74 65 72 |r{Drs. H|ollister|
|000006f0| 20 61 6e 64 20 4c 61 73 | 61 67 6e 61 7d 0d 0a 24 | and Las|agna}..$|
|00000700| 54 61 62 6c 65 7b 7d 0d | 0a 24 43 6f 6d 6d 65 6e |Table{}.|.$Commen|
|00000710| 74 61 74 6f 72 7b 4c 2e | 45 2e 20 48 6f 6c 6c 69 |tator{L.|E. Holli|
|00000720| 73 74 65 72 2c 20 4d 2e | 44 2e 7d 0d 0a 0d 0a 43 |ster, M.|D.}....C|
|00000730| 6f 70 79 72 69 67 68 74 | 20 28 63 29 20 59 65 61 |opyright| (c) Yea|
|00000740| 72 62 6f 6f 6b 20 4d 65 | 64 69 63 61 6c 20 50 75 |rbook Me|dical Pu|
|00000750| 62 6c 69 73 68 65 72 73 | 2c 20 49 6e 63 2e 2c 20 |blishers|, Inc., |
|00000760| 31 39 39 30 0d 0a 0d 0a | 31 39 39 30 20 59 65 61 |1990....|1990 Yea|
|00000770| 72 20 42 6f 6f 6b 20 6f | 66 20 44 72 75 67 20 54 |r Book o|f Drug T|
|00000780| 68 65 72 61 70 79 20 28 | 52 29 0d 0a 0d 0a 43 68 |herapy (|R)....Ch|
|00000790| 61 70 74 65 72 20 31 30 | 2d 2d 49 6e 66 65 63 74 |apter 10|--Infect|
|000007a0| 69 6f 75 73 20 44 69 73 | 65 61 73 65 73 0d 0a 0d |ious Dis|eases...|
|000007b0| 0a 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |.-------|--------|
|000007c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000007d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000007e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000007f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 0d |--------|-------.|
|00000800| 0a 45 66 66 65 63 74 73 | 20 6f 66 20 50 72 6f 6c |.Effects| of Prol|
|00000810| 6f 6e 67 65 64 20 4e 61 | 6c 6f 78 6f 6e 65 20 49 |onged Na|loxone I|
|00000820| 6e 66 75 73 69 6f 6e 20 | 69 6e 20 53 65 70 74 69 |nfusion |in Septi|
|00000830| 63 20 53 68 6f 63 6b 0d | 0a 0d 0a 52 6f 62 65 72 |c Shock.|...Rober|
|00000840| 74 73 20 44 45 3b 20 44 | 6f 62 73 6f 6e 20 4b 45 |ts DE; D|obson KE|
|00000850| 3b 20 48 61 6c 6c 20 4b | 57 3b 20 4c 69 67 68 74 |; Hall K|W; Light|
|00000860| 20 52 42 0d 0a 28 48 65 | 61 6c 74 68 20 53 63 69 | RB..(He|alth Sci|
|00000870| 65 6e 63 65 73 20 43 74 | 72 2c 20 57 69 6e 6e 69 |ences Ct|r, Winni|
|00000880| 70 65 67 2c 20 4d 61 6e | 29 0d 0a 4c 61 6e 63 65 |peg, Man|)..Lance|
|00000890| 74 20 32 3a 36 39 39 2d | 37 30 32 2c 20 53 65 70 |t 2:699-|702, Sep|
|000008a0| 74 20 32 34 2c 20 31 39 | 38 38 0d 0a 2d 2d 2d 2d |t 24, 19|88..----|
|000008b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 0d 0a 41 62 |--------|--....Ab|
|00000900| 73 74 72 61 63 74 0d 0a | 0d 0a 20 20 20 20 20 54 |stract..|.. T|
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|000009c0| 61 20 62 6f 6c 75 73 20 | 61 64 6d 69 6e 69 73 74 |a bolus |administ|
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|00000a70| 78 6f 6e 65 20 69 6e 20 | 68 75 6d 61 6e 20 62 65 |xone in |human be|
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|00000aa0| 65 72 69 65 6e 63 65 64 | 20 73 69 78 74 65 65 6e |erienced| sixteen|
|00000ab0| 20 65 70 69 73 6f 64 65 | 73 20 6f 66 20 73 65 70 | episode|s of sep|
|00000ac0| 74 69 63 20 73 68 6f 63 | 6b 20 77 65 72 65 0d 0a |tic shoc|k were..|
|00000ad0| 72 65 63 72 75 69 74 65 | 64 2c 20 61 6e 64 20 74 |recruite|d, and t|
|00000ae0| 68 65 69 72 20 64 65 70 | 65 6e 64 65 6e 63 65 20 |heir dep|endence |
|00000af0| 6f 6e 20 76 61 73 6f 70 | 72 65 73 73 6f 72 20 6f |on vasop|ressor o|
|00000b00| 72 20 69 6e 6f 74 72 6f | 70 69 63 20 61 67 65 6e |r inotro|pic agen|
|00000b10| 74 20 6f 72 20 62 6f 74 | 68 20 77 61 73 0d 0a 64 |t or bot|h was..d|
|00000b20| 6f 63 75 6d 65 6e 74 65 | 64 2e 0d 0a 20 20 20 20 |ocumente|d... |
|00000b30| 20 4e 61 6c 6f 78 6f 6e | 65 20 77 61 73 20 67 69 | Naloxon|e was gi|
|00000b40| 76 65 6e 20 61 74 20 72 | 61 6e 64 6f 6d 20 74 6f |ven at r|andom to|
|00000b50| 20 38 20 70 61 74 69 65 | 6e 74 73 2c 20 61 6e 64 | 8 patie|nts, and|
|00000b60| 20 70 6c 61 63 65 62 6f | 2c 20 74 6f 20 38 2e 20 | placebo|, to 8. |
|00000b70| 20 49 6e 20 65 61 63 68 | 0d 0a 67 72 6f 75 70 2c | In each|..group,|
|00000b80| 20 37 20 70 61 74 69 65 | 6e 74 73 20 6e 65 65 64 | 7 patie|nts need|
|00000b90| 65 64 20 70 68 65 6e 79 | 6c 65 70 68 72 69 6e 65 |ed pheny|lephrine|
|00000ba0| 20 6f 72 20 64 6f 70 61 | 6d 69 6e 65 2c 20 62 75 | or dopa|mine, bu|
|00000bb0| 74 20 6f 6e 6c 79 20 31 | 20 70 61 74 69 65 6e 74 |t only 1| patient|
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|00000c00| 20 6d 75 5f 67 2f 6b 67 | 0d 0a 69 6e 74 72 61 76 | mu_g/kg|..intrav|
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|00000c20| 6f 77 65 64 20 62 79 20 | 61 6e 20 69 6e 66 75 73 |owed by |an infus|
|00000c30| 69 6f 6e 20 6f 66 20 33 | 30 20 6d 75 5f 67 2f 6b |ion of 3|0 mu_g/k|
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|00000c50| 31 36 0d 0a 68 6f 75 72 | 73 3b 20 74 68 65 20 70 |16..hour|s; the p|
|00000c60| 6c 61 63 65 62 6f 20 28 | 73 61 6c 69 6e 65 29 20 |lacebo (|saline) |
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|00001490| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 4f 6e 65 2d |--------|--..One-|
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|00002280| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00002890| 6d 20 61 6e 20 65 73 74 | 72 6f 67 65 6e 0d 0a 61 |m an est|rogen..a|
|000028a0| 6e 74 61 67 6f 6e 69 73 | 74 20 77 6f 75 6c 64 20 |ntagonis|t would |
|000028b0| 68 61 76 65 20 62 65 65 | 6e 20 62 65 74 74 65 72 |have bee|n better|
|000028c0| 20 73 75 69 74 65 64 2e | 20 20 41 6c 74 68 6f 75 | suited.| Althou|
|000028d0| 67 68 20 74 68 65 20 64 | 69 73 65 61 73 65 2d 66 |gh the d|isease-f|
|000028e0| 72 65 65 20 73 75 72 76 | 69 76 61 6c 0d 0a 77 61 |ree surv|ival..wa|
|000028f0| 73 20 73 6c 69 67 68 74 | 6c 79 20 68 69 67 68 65 |s slight|ly highe|
|00002900| 72 20 69 6e 20 74 68 65 | 20 74 72 65 61 74 65 64 |r in the| treated|
|00002910| 20 67 72 6f 75 70 20 61 | 73 20 63 6f 6d 70 61 72 | group a|s compar|
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|00002930| 65 62 6f 2d 74 72 65 61 | 74 65 64 0d 0a 67 72 6f |ebo-trea|ted..gro|
|00002940| 75 70 2c 20 74 68 65 20 | 64 69 66 66 65 72 65 6e |up, the |differen|
|00002950| 63 65 73 20 77 65 72 65 | 20 6e 6f 74 20 69 6d 70 |ces were| not imp|
|00002960| 72 65 73 73 69 76 65 2e | 20 20 46 75 72 74 68 65 |ressive.| Furthe|
|00002970| 72 2c 20 73 75 72 76 69 | 76 61 6c 20 72 61 74 65 |r, survi|val rate|
|00002980| 73 20 77 65 72 65 20 6e | 6f 74 0d 0a 61 6c 74 65 |s were n|ot..alte|
|00002990| 72 65 64 2e 20 20 54 61 | 6d 6f 78 69 66 65 6e 20 |red. Ta|moxifen |
|000029a0| 6d 61 79 20 73 74 69 6c | 6c 20 62 65 20 77 6f 72 |may stil|l be wor|
|000029b0| 74 68 20 74 72 79 69 6e | 67 2c 20 62 75 74 20 6f |th tryin|g, but o|
|000029c0| 6e 20 74 68 65 20 62 61 | 73 69 73 20 6f 66 20 74 |n the ba|sis of t|
|000029d0| 68 69 73 20 73 74 75 64 | 79 0d 0a 65 6e 74 68 75 |his stud|y..enthu|
|000029e0| 73 69 61 73 6d 20 66 6f | 72 20 69 74 20 6d 75 73 |siasm fo|r it mus|
|000029f0| 74 20 62 65 20 6d 75 74 | 65 64 2e 0d 0a 20 20 20 |t be mut|ed... |
|00002a00| 20 20 54 68 65 20 66 6f | 6c 6c 6f 77 69 6e 67 20 | The fo|llowing |
|00002a10| 61 62 73 74 72 61 63 74 | 20 28 41 62 73 74 72 61 |abstract| (Abstra|
|00002a20| 63 74 20 31 31 2d 32 29 | 20 72 65 70 6f 72 74 73 |ct 11-2)| reports|
|00002a30| 20 73 6f 6d 65 77 68 61 | 74 20 73 69 6d 69 6c 61 | somewha|t simila|
|00002a40| 72 20 72 65 73 75 6c 74 | 73 2e 0d 0a 54 61 6d 6f |r result|s...Tamo|
|00002a50| 78 69 66 65 6e 20 68 61 | 73 20 61 20 62 65 6e 65 |xifen ha|s a bene|
|00002a60| 66 69 63 69 61 6c 20 65 | 66 66 65 63 74 20 69 66 |ficial e|ffect if|
|00002a70| 20 62 6f 74 68 20 65 73 | 74 72 6f 67 65 6e 20 61 | both es|trogen a|
|00002a80| 6e 64 20 70 72 6f 67 65 | 73 74 65 72 6f 6e 65 20 |nd proge|sterone |
|00002a90| 72 65 63 65 70 74 6f 72 | 73 0d 0a 61 72 65 20 70 |receptor|s..are p|
|00002aa0| 6f 73 69 74 69 76 65 20 | 69 6e 20 74 75 6d 6f 72 |ositive |in tumor|
|00002ab0| 73 20 61 6e 64 20 70 72 | 6f 76 69 64 65 73 20 6e |s and pr|ovides n|
|00002ac0| 6f 20 62 65 6e 65 66 69 | 74 20 77 68 65 6e 20 62 |o benefi|t when b|
|00002ad0| 6f 74 68 20 72 65 63 65 | 70 74 6f 72 73 20 61 72 |oth rece|ptors ar|
|00002ae0| 65 0d 0a 6e 65 67 61 74 | 69 76 65 2e 20 20 57 68 |e..negat|ive. Wh|
|00002af0| 65 6e 20 74 61 6d 6f 78 | 69 66 65 6e 20 77 61 73 |en tamox|ifen was|
|00002b00| 20 75 73 65 64 20 69 6e | 20 63 6f 6d 62 69 6e 61 | used in| combina|
|00002b10| 74 69 6f 6e 20 77 69 74 | 68 20 6f 74 68 65 72 20 |tion wit|h other |
|00002b20| 61 64 6a 75 76 61 6e 74 | 20 74 68 65 72 61 70 79 |adjuvant| therapy|
|00002b30| 0d 0a 28 63 79 63 6c 6f | 70 68 6f 73 70 68 61 6d |..(cyclo|phospham|
|00002b40| 69 64 65 2c 20 6d 65 74 | 68 6f 74 72 65 78 61 74 |ide, met|hotrexat|
|00002b50| 65 2c 20 61 6e 64 20 66 | 6c 75 6f 72 6f 75 72 61 |e, and f|luoroura|
|00002b60| 63 69 6c 29 20 69 74 20 | 69 6e 63 72 65 61 73 65 |cil) it |increase|
|00002b70| 64 20 6e 65 69 74 68 65 | 72 20 74 68 65 0d 0a 66 |d neithe|r the..f|
|00002b80| 72 65 65 20 6e 6f 72 20 | 6f 76 65 72 61 6c 6c 20 |ree nor |overall |
|00002b90| 73 75 72 76 69 76 61 6c | 20 61 6d 6f 6e 67 20 6e |survival| among n|
|00002ba0| 6f 64 65 2d 70 6f 73 69 | 74 69 76 65 20 70 61 74 |ode-posi|tive pat|
|00002bb0| 69 65 6e 74 73 2e 20 20 | 4f 6e 63 65 20 61 67 61 |ients. |Once aga|
|00002bc0| 69 6e 2c 20 6f 6e 65 20 | 63 68 65 65 72 0d 0a 66 |in, one |cheer..f|
|00002bd0| 6f 72 20 74 61 6d 6f 78 | 69 66 65 6e 2e 2d 2d 4c |or tamox|ifen.--L|
|00002be0| 2e 45 2e 20 48 6f 6c 6c | 69 73 74 65 72 2c 20 4d |.E. Holl|ister, M|
|00002bf0| 2e 44 2e 0d 0a 24 55 6e | 69 71 75 65 5f 49 44 7b |.D...$Un|ique_ID{|
|00002c00| 59 52 42 31 30 30 30 33 | 7d 0d 0a 24 54 69 74 6c |YRB10003|}..$Titl|
|00002c10| 65 7b 41 64 6a 75 76 61 | 6e 74 20 54 68 65 72 61 |e{Adjuva|nt Thera|
|00002c20| 70 79 20 57 69 74 68 20 | 54 61 6d 6f 78 69 66 65 |py With |Tamoxife|
|00002c30| 6e 20 69 6e 20 4f 70 65 | 72 61 62 6c 65 20 42 72 |n in Ope|rable Br|
|00002c40| 65 61 73 74 20 43 61 6e | 63 65 72 3a 20 20 31 30 |east Can|cer: 10|
|00002c50| 20 59 65 61 72 20 52 65 | 73 75 6c 74 73 20 6f 66 | Year Re|sults of|
|00002c60| 20 74 68 65 20 4e 61 70 | 6c 65 73 20 28 47 55 4e | the Nap|les (GUN|
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|00002c90| 2c 20 50 6c 61 63 69 64 | 6f 20 53 0d 0a 47 61 6c |, Placid|o S..Gal|
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|00002cb0| 6f 2c 20 43 0d 0a 4d 61 | 72 69 6e 65 6c 6c 69 2c |o, C..Ma|rinelli,|
|00002cc0| 20 41 0d 0a 50 65 74 72 | 65 6c 6c 65 2c 20 47 0d | A..Petr|elle, G.|
|00002cd0| 0a 44 27 49 73 74 72 69 | 61 2c 20 4d 0d 0a 44 65 |.D'Istri|a, M..De|
|00002ce0| 6c 72 69 6f 2c 20 47 7d | 0d 0a 24 41 66 66 69 6c |lrio, G}|..$Affil|
|00002cf0| 69 61 74 69 6f 6e 7b 55 | 6e 69 76 20 6f 66 20 4e |iation{U|niv of N|
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|00002d10| 7b 4c 61 6e 63 65 74 7d | 0d 0a 24 56 6f 6c 75 6d |{Lancet}|..$Volum|
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|00002d50| 56 6f 6c 7b 31 39 39 30 | 20 59 65 61 72 20 42 6f |Vol{1990| Year Bo|
|00002d60| 6f 6b 20 6f 66 20 44 72 | 75 67 20 54 68 65 72 61 |ok of Dr|ug Thera|
|00002d70| 70 79 7d 0d 0a 24 43 68 | 61 70 74 65 72 7b 31 31 |py}..$Ch|apter{11|
|00002d80| 2d 32 7d 0d 0a 24 59 42 | 45 64 69 74 6f 72 7b 44 |-2}..$YB|Editor{D|
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|00002df0| 73 2c 20 49 6e 63 2e 2c | 20 31 39 39 30 0d 0a 0d |s, Inc.,| 1990...|
|00002e00| 0a 31 39 39 30 20 59 65 | 61 72 20 42 6f 6f 6b 20 |.1990 Ye|ar Book |
|00002e10| 6f 66 20 44 72 75 67 20 | 54 68 65 72 61 70 79 20 |of Drug |Therapy |
|00002e20| 28 52 29 0d 0a 0d 0a 43 | 68 61 70 74 65 72 20 31 |(R)....C|hapter 1|
|00002e30| 31 2d 2d 4e 65 6f 70 6c | 61 73 74 69 63 20 44 69 |1--Neopl|astic Di|
|00002e40| 73 65 61 73 65 73 0d 0a | 0d 0a 2d 2d 2d 2d 2d 2d |seases..|..------|
|00002e50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002e60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002e70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002e80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002e90| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 41 64 6a 75 76 61 |--------|..Adjuva|
|00002ea0| 6e 74 20 54 68 65 72 61 | 70 79 20 57 69 74 68 20 |nt Thera|py With |
|00002eb0| 54 61 6d 6f 78 69 66 65 | 6e 20 69 6e 20 4f 70 65 |Tamoxife|n in Ope|
|00002ec0| 72 61 62 6c 65 20 42 72 | 65 61 73 74 20 43 61 6e |rable Br|east Can|
|00002ed0| 63 65 72 3a 20 20 31 30 | 20 59 65 61 72 20 52 65 |cer: 10| Year Re|
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|00002f00| 0d 0a 0d 0a 42 69 61 6e | 63 6f 20 41 52 3b 20 44 |....Bian|co AR; D|
|00002f10| 65 20 50 6c 61 63 69 64 | 6f 20 53 3b 20 47 61 6c |e Placid|o S; Gal|
|00002f20| 6c 6f 20 43 3b 20 50 65 | 67 6c 69 61 72 75 6c 6f |lo C; Pe|gliarulo|
|00002f30| 20 43 3b 20 4d 61 72 69 | 6e 65 6c 6c 69 20 41 3b | C; Mari|nelli A;|
|00002f40| 20 50 65 74 72 65 6c 6c | 65 20 47 3b 0d 0a 44 27 | Petrell|e G;..D'|
|00002f50| 49 73 74 72 69 61 20 4d | 3b 20 44 65 6c 72 69 6f |Istria M|; Delrio|
|00002f60| 20 47 0d 0a 28 55 6e 69 | 76 20 6f 66 20 4e 61 70 | G..(Uni|v of Nap|
|00002f70| 6c 65 73 29 0d 0a 4c 61 | 6e 63 65 74 20 32 3a 31 |les)..La|ncet 2:1|
|00002f80| 30 39 35 2d 31 30 39 39 | 2c 20 4e 6f 76 20 31 32 |095-1099|, Nov 12|
|00002f90| 2c 20 31 39 38 38 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |, 1988..|--------|
|00002fa0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002fb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002fc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002fd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002fe0| 2d 2d 2d 2d 2d 2d 0d 0a | 0d 0a 41 62 73 74 72 61 |------..|..Abstra|
|00002ff0| 63 74 0d 0a 0d 0a 20 20 | 20 20 20 49 6e 20 74 68 |ct.... | In th|
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|00003030| 73 2c 20 34 33 33 20 70 | 61 74 69 65 6e 74 73 20 |s, 433 p|atients |
|00003040| 77 69 74 68 0d 0a 73 74 | 61 67 65 20 49 2c 20 49 |with..st|age I, I|
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|00003060| 72 65 61 73 74 20 63 61 | 6e 63 65 72 20 77 65 72 |reast ca|ncer wer|
|00003070| 65 20 74 72 65 61 74 65 | 64 20 77 69 74 68 20 74 |e treate|d with t|
|00003080| 61 6d 6f 78 69 66 65 6e | 2c 20 61 6c 6f 6e 65 20 |amoxifen|, alone |
|00003090| 6f 72 0d 0a 69 6e 20 63 | 6f 6d 62 69 6e 61 74 69 |or..in c|ombinati|
|000030a0| 6f 6e 20 77 69 74 68 20 | 63 79 63 6c 6f 70 68 6f |on with |cyclopho|
|000030b0| 73 70 68 61 6d 69 64 65 | 2c 20 6d 65 74 68 6f 74 |sphamide|, methot|
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|00003110| 30 38 20 70 72 65 6d 65 | 6e 6f 70 61 75 73 61 6c |08 preme|nopausal|
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|000031e0| 6e 6f 64 65 2d 70 6f 73 | 69 74 69 76 65 20 77 6f |node-pos|itive wo|
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|00003350| 20 54 68 65 20 6f 76 65 | 72 61 6c 6c 20 35 2d 79 | The ove|rall 5-y|
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|000033a0| 72 65 63 65 69 76 69 6e | 67 20 74 61 6d 6f 78 69 |receivin|g tamoxi|
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|000033d0| 64 6a 75 76 61 6e 74 20 | 74 68 65 72 61 70 79 2e |djuvant |therapy.|
|000033e0| 0d 0a 53 69 6d 69 6c 61 | 72 6c 79 2c 20 6d 6f 72 |..Simila|rly, mor|
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|00003440| 6e 64 65 70 65 6e 64 65 | 6e 74 20 6f 66 20 6d 65 |ndepende|nt of me|
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|00003570| 61 7a 61 72 64 73 20 6f | 66 20 72 65 6c 61 70 73 |azards o|f relaps|
|00003580| 65 20 77 65 72 65 20 73 | 69 6d 69 6c 61 72 20 61 |e were s|imilar a|
|00003590| 6e 64 20 68 61 6c 66 20 | 74 68 65 20 76 61 6c 75 |nd half |the valu|
|000035a0| 65 0d 0a 6f 66 20 74 68 | 6f 73 65 20 69 6e 20 65 |e..of th|ose in e|
|000035b0| 73 74 72 6f 67 65 6e 20 | 72 65 63 65 70 74 6f 72 |strogen |receptor|
|000035c0| 2d 70 72 6f 67 65 73 74 | 65 72 6f 6e 65 20 72 65 |-progest|erone re|
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|000043b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004400| 43 68 65 6d 6f 74 68 65 | 72 61 70 79 3a 20 20 41 |Chemothe|rapy: A|
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|00004420| 0a 54 61 62 62 61 72 61 | 20 49 41 3b 20 51 75 65 |.Tabbara| IA; Que|
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|000044c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000044d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000044e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 0d 0a 41 62 |--------|--....Ab|
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|00004920| 20 31 20 6f 66 20 61 20 | 73 74 72 6f 6b 65 20 61 | 1 of a |stroke a|
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|00004e80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004e90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004ef0| 43 61 6e 63 65 72 0d 0a | 0d 0a 4d 6f 72 69 74 74 |Cancer..|..Moritt|
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|00004fa0| 6f 6d 70 74 6f 6e 20 48 | 6f 73 70 2c 20 4c 6f 6e |ompton H|osp, Lon|
|00004fb0| 64 6f 6e 29 0d 0a 42 72 | 20 4a 20 43 61 6e 63 65 |don)..Br| J Cance|
|00004fc0| 72 20 33 39 3a 38 30 31 | 2d 38 30 34 2c 20 4d 61 |r 39:801|-804, Ma|
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|00005000| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005010| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005020| 2d 2d 2d 2d 2d 2d 0d 0a | 0d 0a 41 62 73 74 72 61 |------..|..Abstra|
|00005030| 63 74 0d 0a 0d 0a 20 20 | 20 20 20 52 65 63 65 6e |ct.... | Recen|
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|00005070| 6c 6c 20 6c 75 6e 67 20 | 63 61 6e 63 65 72 0d 0a |ll lung |cancer..|
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|00005190| 20 4f 66 20 74 68 65 20 | 36 31 30 20 70 61 74 69 | Of the |610 pati|
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|000051e0| 28 31 31 2e 36 25 29 20 | 64 69 65 64 20 69 6e 20 |(11.6%) |died in |
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|00005390| 72 20 73 65 72 75 6d 20 | 61 6c 62 75 6d 69 6e 0d |r serum |albumin.|
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|00005480| 20 77 69 74 68 20 61 6c | 74 65 72 65 64 20 70 68 | with al|tered ph|
|00005490| 61 72 6d 61 63 6f 6b 69 | 6e 65 74 69 63 73 20 6f |armacoki|netics o|
|000054a0| 66 0d 0a 65 74 6f 70 6f | 73 69 64 65 2e 20 20 49 |f..etopo|side. I|
|000054b0| 74 20 69 73 20 61 6c 73 | 6f 20 70 72 6f 62 61 62 |t is als|o probab|
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|00005500| 72 65 20 6e 65 75 74 72 | 6f 70 65 6e 69 63 20 61 |re neutr|openic a|
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|00005530| 74 69 63 20 61 6e 74 69 | 62 69 6f 74 69 63 0d 0a |tic anti|biotic..|
|00005540| 63 6f 76 65 72 61 67 65 | 20 6f 72 20 64 6f 73 61 |coverage| or dosa|
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|00005580| 68 65 73 65 20 68 69 67 | 68 2d 72 69 73 6b 0d 0a |hese hig|h-risk..|
|00005590| 70 61 74 69 65 6e 74 73 | 2e 0d 0a 0d 0a 50 6f 73 |patients|.....Pos|
|000055a0| 74 2d 43 6f 6d 6d 65 6e | 74 0d 0a 0d 0a 20 20 20 |t-Commen|t.... |
|000055b0| 20 20 4d 6f 73 74 20 70 | 61 74 69 65 6e 74 73 20 | Most p|atients |
|000055c0| 77 69 74 68 20 74 68 69 | 73 20 63 61 6e 63 65 72 |with thi|s cancer|
|000055d0| 20 68 61 76 65 20 65 78 | 74 65 6e 73 69 76 65 20 | have ex|tensive |
|000055e0| 64 69 73 65 61 73 65 20 | 77 68 65 6e 20 66 69 72 |disease |when fir|
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|00005600| 68 61 76 65 20 6c 65 73 | 73 20 74 68 61 6e 20 32 |have les|s than 2|
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|00005630| 76 69 76 61 6c 20 69 73 | 20 38 2d 31 30 20 6d 6f |vival is| 8-10 mo|
|00005640| 6e 74 68 73 2e 0d 0a 20 | 20 20 20 20 54 68 65 20 |nths... | The |
|00005650| 70 72 65 73 65 6e 74 20 | 61 6e 61 6c 79 73 69 73 |present |analysis|
|00005660| 20 73 75 67 67 65 73 74 | 73 20 74 68 61 74 20 63 | suggest|s that c|
|00005670| 65 72 74 61 69 6e 20 70 | 61 74 69 65 6e 74 73 20 |ertain p|atients |
|00005680| 61 74 20 68 69 67 68 20 | 72 69 73 6b 20 66 72 6f |at high |risk fro|
|00005690| 6d 0d 0a 63 68 65 6d 6f | 74 68 65 72 61 70 79 20 |m..chemo|therapy |
|000056a0| 73 68 6f 75 6c 64 20 67 | 65 74 20 65 69 74 68 65 |should g|et eithe|
|000056b0| 72 20 61 20 73 6d 61 6c | 6c 65 72 20 64 6f 73 65 |r a smal|ler dose|
|000056c0| 20 69 6e 20 74 68 65 20 | 66 69 72 73 74 20 63 79 | in the |first cy|
|000056d0| 63 6c 65 20 6f 72 0d 0a | 70 72 6f 70 68 79 6c 61 |cle or..|prophyla|
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|00005720| 65 2e 2d 2d 4c 2e 0d 0a | 4c 61 73 61 67 6e 61 2c |e.--L...|Lasagna,|
|00005730| 20 4d 2e 44 2e 0d 0a 24 | 55 6e 69 71 75 65 5f 49 | M.D...$|Unique_I|
|00005740| 44 7b 59 52 42 31 30 30 | 30 37 7d 0d 0a 24 54 69 |D{YRB100|07}..$Ti|
|00005750| 74 6c 65 7b 43 68 65 6d | 6f 74 68 65 72 61 70 79 |tle{Chem|otherapy|
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|00005780| 73 7d 0d 0a 24 41 75 74 | 68 6f 72 7b 48 61 6c 6c |s}..$Aut|hor{Hall|
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|000057c0| 75 72 6e 61 6c 7b 53 65 | 6d 69 6e 20 4f 6e 63 6f |urnal{Se|min Onco|
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|000057e0| 0a 24 50 61 67 65 7b 35 | 30 2d 36 34 7d 0d 0a 24 |.$Page{5|0-64}..$|
|000057f0| 44 61 74 65 7b 4a 75 6e | 65 20 31 39 38 38 7d 0d |Date{Jun|e 1988}.|
|00005800| 0a 24 59 42 56 6f 6c 7b | 31 39 39 30 20 59 65 61 |.$YBVol{|1990 Yea|
|00005810| 72 20 42 6f 6f 6b 20 6f | 66 20 44 72 75 67 20 54 |r Book o|f Drug T|
|00005820| 68 65 72 61 70 79 7d 0d | 0a 24 43 68 61 70 74 65 |herapy}.|.$Chapte|
|00005830| 72 7b 31 31 2d 36 7d 0d | 0a 24 59 42 45 64 69 74 |r{11-6}.|.$YBEdit|
|00005840| 6f 72 7b 44 72 73 2e 20 | 48 6f 6c 6c 69 73 74 65 |or{Drs. |Holliste|
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|00005860| 24 54 61 62 6c 65 7b 7d | 0d 0a 24 43 6f 6d 6d 65 |$Table{}|..$Comme|
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|000058c0| 39 30 0d 0a 0d 0a 31 39 | 39 30 20 59 65 61 72 20 |90....19|90 Year |
|000058d0| 42 6f 6f 6b 20 6f 66 20 | 44 72 75 67 20 54 68 65 |Book of |Drug The|
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|00005920| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005930| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005940| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005950| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 0d 0a 43 |--------|-----..C|
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|00005980| 4d 61 6c 69 67 6e 61 6e | 63 69 65 73 0d 0a 0d 0a |Malignan|cies....|
|00005990| 48 61 6c 6c 65 72 20 44 | 47 0d 0a 28 55 6e 69 76 |Haller D|G..(Univ|
|000059a0| 20 6f 66 20 50 65 6e 6e | 73 79 6c 76 61 6e 69 61 | of Penn|sylvania|
|000059b0| 29 0d 0a 53 65 6d 69 6e | 20 4f 6e 63 6f 6c 20 31 |)..Semin| Oncol 1|
|000059c0| 35 3a 35 30 2d 36 34 2c | 20 4a 75 6e 65 20 31 39 |5:50-64,| June 19|
|000059d0| 38 38 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |88..----|--------|
|000059e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000059f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005a00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005a10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005a20| 2d 2d 0d 0a 0d 0a 41 62 | 73 74 72 61 63 74 0d 0a |--....Ab|stract..|
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|00005d10| 63 20 63 61 6e 63 65 72 | 2e 0d 0a 20 20 20 20 20 |c cancer|... |
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|00005d70| 72 75 62 69 63 69 6e 20 | 61 6e 64 20 35 2d 46 55 |rubicin |and 5-FU|
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+--------+-------------------------+-------------------------+--------+--------+
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